Assessing the feasibility and impact of clinical trial trustworthiness checks via an application to Cochrane Reviews: Stage 2 of the INSPECT-SR project
Applies candidate trustworthiness checks to 95 trials in 50 Cochrane reviews to evaluate their feasibility and impact, while identifying checks that were difficult to interpret or perform.
Open-science resources
- Open access: Free full text (repository)
- Shared data: Shared trustworthiness assessment data
- Shared code: Analysis code
- Preprint: Earlier preprint
Resource verification & source notes
- Free full text (repository): The complete published article PDF was downloaded from the coauthor institutional repository and its text was inspected.
- Shared trustworthiness assessment data: The main text explicitly links this repository for its dataset and analysis code. The public inventory includes datshare.csv, codeshare.r and the extraction workbook.
- Analysis code: The main text explicitly links this repository for its dataset and analysis code. The public inventory includes datshare.csv, codeshare.r and the extraction workbook.
- Earlier preprint: Matched title / source version grouping.
Publication details
Research themes
Author affiliations & identifiers
- Jack Wilkinson: Centre for Biostatistics, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
- Calvin Heal: Centre for Biostatistics, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK. Electronic address: calvin.heal@manchester.ac.uk.
- Georgios A Antoniou: Manchester Vascular Centre, Manchester University NHS Foundation Trust, Manchester, UK; Division of Cardiovascular Sciences, School of Medical Sciences, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.
- Ella Flemyng: Evidence Production and Methods Directorate, Cochrane Central Executive, London, UK.
- Love Ahnström: Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
- Alessandra Alteri: Obstetrics and Gynaecology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
- Alison Avenell: Aberdeen Centre for Evaluation, University of Aberdeen, Aberdeen, UK.
- Timothy Hugh Barker: Health Evidence Synthesis, Recommendations and Impact, School of Public Health, The University of Adelaide, Adelaide, South Australia, Australia.
- David N Borg: Australian Sports Commission, Australian Institute of Sport, Bruce, Australian Capital Territory, Australia; Queensland University of Technology, School of Exercise Nutrition Sciences, Brisbane, Queensland, Australia.
- Nicholas J L Brown: Department of Psychology, Linnaeus University, Växjö, Sweden.
- Rob Buhmann: University of the Sunshine Coast, School of Health, Queensland, Australia.
- Jose A Calvache: Department of Anesthesiology, Erasmus MC, Rotterdam, The Netherlands; Department of Anesthesiology, Universidad del Cauca, Popayán, Colombia.
- Rickard Carlsson: Department of Psychology, Linnaeus University, Växjö, Sweden.
- Lesley-Anne Carter: Centre for Biostatistics, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
- Aidan G Cashin: Centre for Pain IMPACT, Neuroscience Research Australia, Randwick, Australia; School of Health Sciences, Faculty of Medicine and Health, University of New South Wales Sydney, Sydney, Australia.
- Sarah Cotterill: Centre for Biostatistics, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
- Kenneth Färnqvist: Department of Molecular medicine and surgery, Karolinska Institute, Stockholm, Sweden.
- Michael C Ferraro: Centre for Pain IMPACT, Neuroscience Research Australia, Randwick, Australia; School of Health Sciences, Faculty of Medicine and Health, University of New South Wales Sydney, Sydney, Australia.
- Steph Grohmann: Evidence Production and Methods Directorate, Cochrane Central Executive, London, UK.
- Lyle C Gurrin: School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
- Jill A Hayden: Department of Community Health & Epidemiology, Dalhousie University, Halifax, Canada.
- Kylie E Hunter: NHMRC Clinical Trials Centre, University of Sydney, Sydney, Australia.
- Natalie Hyltse: Department of Psychology, Linnaeus University, Växjö, Sweden.
- Lukas Jung: Independent Researcher, Heidelberg, Germany.
- Ashma Krishan: Centre for Biostatistics, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
- Silvy Laporte: Clinical Pharmacology Unit, INSERM U1059 Sainbiose, University Hospital of Saint-Etienne, Saint-Etienne, France.
- Toby J Lasserson: Evidence Production and Methods Directorate, Cochrane Central Executive, London, UK.
- David R T Laursen: Cochrane Denmark & Centre for Evidence-Based Medicine Odense (CEBMO), Department of Clinical Research, University of Southern Denmark, Odense, Denmark; Open Patient data Explorative Network (OPEN), Odense University Hospital, Odense, Denmark.
- Sarah Lensen: Department of Obstetrics, Gynaecology and Newborn Health, Royal Women's Hospital, University of Melbourne, Melbourne, Victoria, Australia.
- Wentao Li: National Perinatal Epidemiology and Statistics Unit, Centre for Big Data Research in Health and School of Women's and Children's Health, The University of New South Wales, Sydney, Australia.
- Tianjing Li: Department of Ophthalmology and Department of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
- Jianping Liu: Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
- Clara Locher: Univ Rennes, CHU Rennes, Inserm, Irset [(Institut de recherche en santé, environnement et travail)] - UMR_S 1085, F-35000 Rennes, France.
- Zewen Lu: Centre for Biostatistics, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
- Andreas Lundh: Cochrane Denmark & Centre for Evidence-Based Medicine Odense (CEBMO), Department of Clinical Research, University of Southern Denmark, Odense, Denmark; Open Patient data Explorative Network (OPEN), Odense University Hospital, Odense, Denmark; Department of Respiratory Medicine and Infectious Diseases, Copenhagen University Hospital, Copenhagen, Bispebjerg and Frederiksberg, Denmark.
- Antonia Marsden: Centre for Biostatistics, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
- Gideon Meyerowitz-Katz: School of Nursing, University of Wollongong, Wollongong, New South Wales, Australia.
- Ben W Mol: Department of Obstetrics, Gynaecology and Newborn Health, Royal Women's Hospital, University of Melbourne, Melbourne, Victoria, Australia.
- Zachary Munn: National Perinatal Epidemiology and Statistics Unit, Centre for Big Data Research in Health and School of Women's and Children's Health, The University of New South Wales, Sydney, Australia.
- Florian Naudet: Univ Rennes, CHU Rennes, Inserm, Irset [(Institut de recherche en santé, environnement et travail)] - UMR_S 1085, F-35000 Rennes, France.
- David Nunan: Centre for Evidence-Based Medicine, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
- Neil E O'Connell: Department of Health Sciences, Centre for Health and Wellbeing across the Lifecourse, Brunel University London, London, UK.
- Natasha Olsson: Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
- Lisa Parker: Faculty of Medicine & Health, Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.
- Eleftheria Patetsini: York Trials Unit, Department of Health Sciences, University of York, York, UK.
- Barbara Redman: Division of Medical Ethics, New York University Grossman School of Medicine, New York, NY, USA.
- Sarah Rhodes: Centre for Biostatistics, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
- Rachel Richardson: Evidence Production and Methods Directorate, Cochrane Central Executive, London, UK.
- Martin Ringsten: Cochrane Sweden, Skåne University Hospital, Lund University, Lund, Sweden.
- Ewelina Rogozińska: Meta-Analysis Group, MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, London, UK.
- Anna Lene Seidler: NHMRC Clinical Trials Centre, University of Sydney, Sydney, Australia; Department of Child and Adolescent Psychiatry, University Medical Centre Rostock, Rostock, Germany; German Center for Child and Adolescent Health (DZKJ), partner site Greifswald/Rostock, Rostock, Germany.
- Kyle Sheldrick: Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
- Katie Stocking: Centre for Biostatistics, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
- Emma Sydenham: Cochrane Central Editorial Service, Cochrane Database of Systematic Reviews, London, UK.
- Hugh Thomas: The Lancet Gastroenterology & Hepatology, London, UK.
- Sofia Tsokani: Laboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
- Constant Vinatier: Univ Rennes, CHU Rennes, Inserm, Irset [(Institut de recherche en santé, environnement et travail)] - UMR_S 1085, F-35000 Rennes, France.
- Colby J Vorland: Department of Epidemiology and Biostatistics, Indiana University School of Public Health-Bloomington, Bloomington, IN, USA.
- Rui Wang: NHMRC Clinical Trials Centre, University of Sydney, Sydney, Australia.
- Bassel H Al Wattar: Clinical Trials Unit, Anglia Ruskin University, Chelmsford, UK.
- Florencia Weber: Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Würzburg, Würzburg, Germany.
- Stephanie Weibel: Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Würzburg, Würzburg, Germany.
- Madelon van Wely: Centre for Reproductive Medicine, Department of Obstetrics and Gynaecology, Amsterdam University Medical Center, Amsterdam, The Netherlands.
- Chang Xu: The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Third Affiliated Hospital, Second Military Medical University, Naval Medical University, Shanghai, China; Proof of Concept Center, Eastern Hepatobiliary Surgery Hospital, Third Affiliated Hospital, Second Military Medical University, Naval Medical University, Shanghai, China.
- Lisa Bero: Center for Bioethics, and Humanities, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
- Jamie J Kirkham: Centre for Biostatistics, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Preprint & version links
Source notes
- CV abbreviates the ordered author list with ellipses; replace with complete authoritative list before displaying full authors.