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2022 · Review · Nature aging

Randomization, design and analysis for interdependency in aging research: no person or mouse is an island

Daniella E Chusyd; Steven N Austad; Stephanie L Dickinson; Keisuke Ejima; Gary L Gadbury; Lilian Golzarri-Arroyo; Richard J Holden; Yasaman Jamshidi-Naeini; Doug Landsittel; Tapan Mehta; J Michael Oakes; Arthur H Owora; Greg Pavela; Javier Rojo; Michael W Sandel; Daniel L Smith Jr; Colby J Vorland; Pengcheng Xun; Roger Zoh; David B Allison

Explains how interdependence between study participants or animals affects randomized designs and offers approaches to improve analysis in aging research.

Open-science resources

Resource verification & source notes
  • Free full text (PMC): The complete article body was retrieved from the public NCBI PMC JATS endpoint. This confirms free access; reuse permissions depend on the individual article license.

Publication details

Research themes

Statistical rigorNutrition & aging

aging · animal-models · clinical-trials

Author affiliations & identifiers
  • Daniella E Chusyd: Department of Environmental and Occupational Health, Indiana University-Bloomington, Bloomington, IN, USA. · ORCID 0000-0002-9867-944X
  • Steven N Austad: Department of Biology, University of Alabama at Birmingham, Birmingham, AL, USA.; Nathan Shock Center, University of Alabama at Birmingham, Birmingham, AL, USA. · ORCID 0000-0003-4798-8442
  • Stephanie L Dickinson: Department of Epidemiology and Biostatistics, Indiana University-Bloomington, Bloomington, IN, USA. · ORCID 0000-0002-2998-4467
  • Keisuke Ejima: Department of Epidemiology and Biostatistics, Indiana University-Bloomington, Bloomington, IN, USA. · ORCID 0000-0002-1185-3987
  • Gary L Gadbury: Departments of Statistics, Kansas State University, Manhattan, KS, USA.
  • Lilian Golzarri-Arroyo: Department of Epidemiology and Biostatistics, Indiana University-Bloomington, Bloomington, IN, USA. · ORCID 0000-0002-1221-6701
  • Richard J Holden: Department of Health & Wellness Design, Indiana University-Bloomington, Bloomington, IN, USA.
  • Yasaman Jamshidi-Naeini: Department of Epidemiology and Biostatistics, Indiana University-Bloomington, Bloomington, IN, USA. · ORCID 0000-0003-4769-2764
  • Doug Landsittel: Department of Epidemiology and Biostatistics, Indiana University-Bloomington, Bloomington, IN, USA.
  • Tapan Mehta: Department of Family and Community Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
  • J Michael Oakes: Department of Quantitative Health Science, Case Western Reserve University, Cleveland, OH, USA.
  • Arthur H Owora: Department of Epidemiology and Biostatistics, Indiana University-Bloomington, Bloomington, IN, USA.
  • Greg Pavela: School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Javier Rojo: Department of Epidemiology and Biostatistics, Indiana University-Bloomington, Bloomington, IN, USA.
  • Michael W Sandel: Department of Wildlife, Fisheries and Aquaculture, Mississippi State University, Starkville, MS, USA. · ORCID 0000-0001-9083-9202
  • Daniel L Smith Jr: Nathan Shock Center, University of Alabama at Birmingham, Birmingham, AL, USA.; Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Colby J Vorland: Department of Applied Health Science, Indiana University-Bloomington, Bloomington, IN, USA. · ORCID 0000-0003-4225-372X
  • Pengcheng Xun: Department of Epidemiology and Biostatistics, Indiana University-Bloomington, Bloomington, IN, USA.; Department of Global Value, Access and Outcomes, Atara Biotherapeutics, Thousand Oaks, CA, USA. · ORCID 0000-0002-6245-4505
  • Roger Zoh: Department of Epidemiology and Biostatistics, Indiana University-Bloomington, Bloomington, IN, USA.
  • David B Allison: Department of Epidemiology and Biostatistics, Indiana University-Bloomington, Bloomington, IN, USA. · ORCID 0000-0003-3566-9399

Versions & associated materials

These items belong to this research work. Their individual titles, author lists, and source identifiers are preserved below.

Author Correction: Randomization, design and analysis for interdependency in aging research: no person or mouse is an island

Correction · 2023 · Nature aging

Daniella E Chusyd; Steven N Austad; Stephanie L Dickinson; Keisuke Ejima; Gary L Gadbury; Lilian Golzarri-Arroyo; Richard J Holden; Yasaman Jamshidi-Naeini; Doug Landsittel; Tapan Mehta; J Michael Oakes; Arthur H Owora; Greg Pavela; Javier Rojo; Michael W Sandel; Daniel L Smith Jr; Colby J Vorland; Pengcheng Xun; Roger Zoh; David B Allison

DOI: 10.1038/s43587-023-00367-4

Related materials

Source notes
  • CV abbreviates the ordered author list with ellipses; replace with complete authoritative list before displaying full authors.

Metadata sources: PubMed, OpenAlex, CV, Google Scholar. Classification is an editorial interpretation of the title, abstract, and supplied CV.