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2025 · Article · The American journal of clinical nutrition

Describing the landscape of nutrition- and diet-related randomized controlled trials: metaresearch study of protocols published between 2012 and 2022

Flávia Moraes Silva; Amanda Rodrigues Amorim Adegboye; Celeste Naude; Cintia Curioni; Fabio S Gomes; Gary S Collins; Gilberto Kac; Jennifer Anne de Beyer; Jonathan Cook; Leila Cheikh Ismail; Matthew J Page; Neha Khandpur; Sallie Lamb; Sally Hopewell; Shaima Saleh; Shona Kirtley; Simone Bernardes; Solange Durão; Colby J Vorland; Michael Maia Schlussel

Maps 1,068 published nutrition-trial protocols, describing their intervention designs, transparency practices, and use of reporting guidelines.

Open-science resources

Resource verification & source notes
  • Free full text (PMC): The complete article body was retrieved from the public NCBI PMC JATS endpoint. This confirms free access; reuse permissions depend on the individual article license.
  • Shared extracted protocol data: The article names YWEVS for data/code. Its registration points back to STAR-NUT project B38Z9, whose landscape folder publicly contains the study database and SPSS syntax.
  • SPSS analysis code: The article names YWEVS for data/code. Its registration points back to STAR-NUT project B38Z9, whose landscape folder publicly contains the study database and SPSS syntax.
  • Study registration: The article explicitly identifies YWEVS as its study registration; the public registration record confirms its title and 2022 registration date.
  • Published protocol: The article explicitly cites its previously published full protocol, which matches the 2012–2022 nutrition RCT-protocol landscape study.
  • Earlier preprint: Saved catalogue version matching based on title, ordered byline, and study content; prior manuscript DOI retained.

Publication details

Research themes

Reporting transparencyNutrition & aging

nutrition · clinical-trials

Author affiliations & identifiers
  • Flávia Moraes Silva: Nutrition Department and Graduate Program of Nutrition Science, Federal University of Health Science of Porto Alegre, Porto Alegre, Brazil.
  • Amanda Rodrigues Amorim Adegboye: Centre for Healthcare Research and School of Nursing, Midwifery and Health, Faculty of Health and Life Sciences, Coventry University, Centre for Agroecology, Water and Resilience, Coventry, United Kingdom.
  • Celeste Naude: Centre for Evidence-based Health Care, Department of Global Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
  • Cintia Curioni: Department of Nutrition in Public Health, University of the State of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Fabio S Gomes: Pan-American Health Organization, World Health Organization, Washington, DC, United States.
  • Gary S Collins: UK EQUATOR Centre, Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.
  • Gilberto Kac: Nutritional Epidemiology Observatory, Department of Social and Applied Nutrition, Institute of Nutrition Josué de Castro, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Jennifer Anne de Beyer: UK EQUATOR Centre, Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.
  • Jonathan Cook: Oxford Clinical Trials Research Unit, Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.
  • Leila Cheikh Ismail: Department of Clinical Nutrition and Dietetics, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates; Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, United Kingdom.
  • Matthew J Page: Methods in Evidence Synthesis Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
  • Neha Khandpur: Division of Human Nutrition and Health, Wageningen University, the Netherlands; Department of Nutrition, University of São Paulo, São Paulo, Brazil; Department of Nutrition, Harvard T.H. Chan School of Public Health, Harvard, Boston, MA, United States.
  • Sallie Lamb: Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom.
  • Sally Hopewell: Oxford Clinical Trials Research Unit, Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.
  • Shaima Saleh: Department of Clinical Nutrition and Dietetics, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.
  • Shona Kirtley: UK EQUATOR Centre, Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.
  • Simone Bernardes: Nutrition Department and Graduate Program of Nutrition Science, Federal University of Health Science of Porto Alegre, Porto Alegre, Brazil.
  • Solange Durão: Health Systems Research Unit, South African Medical Research Council, South Africa.
  • Colby J Vorland: Department of Applied Health Science, Indiana University School of Public Health-Bloomington, Bloomington, IN, United States.
  • Michael Maia Schlussel: UK EQUATOR Centre, Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom. Electronic address: michael.schlussel@csm.ox.ac.uk.

Versions & associated materials

These items belong to this research work. Their individual titles, author lists, and source identifiers are preserved below.

Describing the landscape of nutrition or diet-related randomised controlled trials: meta-research study of protocols published between 2012 and 2022

Preprint · 2023 · medRxiv

Flávia Moraes Silva; Amanda Rodrigues Amorim Adegboye; Cintia Curioni; Fabio Gomes; Gary S Collins; Gilberto Kac; Jonathan Cook; Leila Cheikh Ismail; Matthew J Page; Neha Khandpur; Sarah Sallie Lamb; Sally Hopewell; Shaima Saleh; Shona Kirtley; Simone Bernardes; Solange Durão; Colby J Vorland; Michael Schlussel

DOI: 10.1101/2023.06.08.23291109

Preprint & version links

Related materials

Source notes
  • CV abbreviates the ordered author list with ellipses; replace with complete authoritative list before displaying full authors.

Metadata sources: PubMed, OpenAlex, CV, Google Scholar. Classification is an editorial interpretation of the title, abstract, and supplied CV.