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2024 · Article · F1000Research

Adjusting for covariates representing potential confounders, mediators, or competing predictors in the presence of measurement error: Dispelling a potential misapprehension and insights for optimal study design with nutritional epidemiology examples

Roger S Zoh; Diana M Thomas; Carmen D Tekwe; Xiaoxin Yu; Colby J Vorland; Nikhil V Dhurandhar; David M Klurfeld; David B Allison

Uses mathematical derivations and simulations to examine how measurement error changes the consequences of adjusting for covariates in observational studies.

Open-science resources

Resource verification & source notes
  • Free full text (PMC): The complete article body was retrieved from the public NCBI PMC JATS endpoint. This confirms free access; reuse permissions depend on the individual article license.
  • ReliabME analysis code: The availability statement links the analysis code repository; the public GitHub tree includes R/MainCode.R.
  • Archived analysis code: The article links this archived ReliabME release. Zenodo lists a downloadable versioned software archive, not a separate empirical dataset.

Publication details

Research themes

Statistical rigorNutrition & aging

nutrition · epidemiology

Author affiliations & identifiers
  • Roger S Zoh: Department of Epidemiology and Biostatistics, Indiana University Bloomington, Bloomington, Indiana, 47408, USA. · ORCID 0000-0002-8066-1153
  • Diana M Thomas: Department of Mathematical Sciences, West Point United States Military Academy, New York, NY, USA.
  • Carmen D Tekwe: Department of Epidemiology and Biostatistics, Indiana University Bloomington, Bloomington, Indiana, 47408, USA.
  • Xiaoxin Yu: Department of Epidemiology and Biostatistics, Indiana University Bloomington, Bloomington, Indiana, 47408, USA.
  • Colby J Vorland: Department of Applied Health Science, Indiana University Bloomington, Bloomington, Indiana, 47408, USA. · ORCID 0000-0003-4225-372X
  • Nikhil V Dhurandhar: Department of Nutritional Sciences, Texas Tech University, Lubbock, Texas, USA. · ORCID 0000-0002-1356-1064
  • David M Klurfeld: Department of Applied Health Science, Indiana University Bloomington, Bloomington, Indiana, 47408, USA. · ORCID 0000-0001-7093-3998
  • David B Allison: Department of Epidemiology and Biostatistics, Indiana University Bloomington, Bloomington, Indiana, 47408, USA.
Source notes
  • CV abbreviates the ordered author list with ellipses; replace with complete authoritative list before displaying full authors.

Metadata sources: PubMed, OpenAlex, CV, Google Scholar. Classification is an editorial interpretation of the title, abstract, and supplied CV.